Hepato-protective effect of ethanol extract of Pterocarpussantalinoides leaf on CCl4-induced hepatic damage in albino rats was carried out with a total of 25 rats. CCl4 wasadministered in two groups; one group was not treated while the other groups were administered Pterocarpussantalinoides ethanol leaf extract at 100,200 and 400 mg/kg body weight of rats twice for 1 week followed administration of CCl4 at the 7th day via intra-peritoneal route respectively. One group was not induced and received distilled water only. The Liver enzymes activities were determined from plasma transaminase activities of the rats. Twenty five albino rats were grouped into A, B and C. Group C was further subdivided into C1, C2 and C3 respectively. CCl4 was administered to all the groups except group A (Normal Control). Group B (Positive Control) was not treated while group C1to C3 received ethanol extract of P. santalinoidesleaf which was administered orally to the rats twice daily for 1 week at varying doses of 100, 200 and 400 mg/kg body weight respectively. The liver enzymes activities were determined using spectrophotometric method. The result revealed that there were significant (P<0.05) reductions in aspartate aminotransaminase (AST), alanine aminotransaminase (ALT) and alkaline phosphatase (ALP) activities in rats administered ethanol extract of P. santalinoidesleaf in a dose dependent manner while significant(p<0.05) increase in the activities of AST, ALT and ALP were recorded in the group that received only CCl4 . The results of histological analysis showed that the ethanol extract of P. santalinoidesleaf was able to prevent CCl4 from damaging the liver architecture in a dose dependent manner. The results indicate that P. santalinoidesleaf possesses hepato-protective property.
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