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Article Subject
Biology
Abstract

Hepato-protective effect of ethanol extract of Pterocarpussantalinoides leaf on CCl4­-induced hepatic damage in albino rats was carried out with a total of 25 rats. CCl4  wasadministered in two groups; one group was not treated while the other groups were administered Pterocarpussantalinoides ethanol leaf extract at 100,200 and 400 mg/kg body weight of rats twice for 1 week followed administration of CCl4  at the 7th  day via intra-peritoneal  route respectively. One group was not induced and received distilled water only. The Liver enzymes activities were determined from plasma transaminase activities of the rats. Twenty five albino rats were grouped into A, B and C. Group C was further subdivided into C1, C2 and C3 respectively. CCl4 was administered to all the groups except group A (Normal Control). Group B (Positive Control) was not treated while group C1to C3 received ethanol extract of P. santalinoidesleaf which was administered orally to the rats twice daily for 1 week at varying doses of 100, 200 and 400 mg/kg body weight respectively. The liver enzymes activities were determined using spectrophotometric method. The result revealed that there were significant (P<0.05) reductions in aspartate aminotransaminase (AST), alanine aminotransaminase (ALT) and alkaline phosphatase (ALP) activities in rats administered ethanol extract of P. santalinoidesleaf in a dose dependent manner while significant(p<0.05) increase  in the activities of AST, ALT and ALP were recorded in the group that received  only CCl4 . The results of histological analysis showed that the ethanol extract of P. santalinoidesleaf was able to prevent CCl4 from damaging the liver architecture in a dose dependent manner. The results indicate that P. santalinoidesleaf possesses hepato-protective property.

Keywords
Hepato-protective
Pterocarpussantalinoides
aspartate aminotransaminase
alanine aminotransaminase
alkaline phosphatase and histological analysis.
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