Synthesis and Characterization of Novel Atazanavir Analogs

Authors

  • V. Pandu Ranga Rao
  • N. Senthil Kumar
  • Shankar B. Reddy
  • H. B. Bollikolla

Keywords:

Carbamate amino acid; carbazole; hydrazine; human immunodeficiency virus; HIV-1 protease inhibitors; atazanavir

Abstract

In this work, we report the synthesis of diverse atazanavir analogues as possible potential novel drugs for human immunodeficiency virus (HIV-1). The synthesis was carried as follows: First, condensation of 4-oxiranylmethoxy-9H-carbazole (1) with N-1-(tert-butyloxycarbonyl)-N-2-(4-(pyridine-2-yl)-benzyl) hydrazine (2) in presence of isopropyl alcohol at 70-75 °C followed by deprotection with
mineral acid yielded intermediate 4 which was subsequently coupled with carbamate amino acid (5a-o) in the presence of EDAC.HCl and HOBt at room temperature to produce atazanavir analogues containing the carbazole moiety (6a10c). These compounds were characterized by the following analytical methods: IR, 1H NMR, 13C NMR and mass spectroscopy.

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Published

31-12-2017

How to Cite

Rao, V. P. R. ., Kumar, N. S. ., Reddy, S. B. ., & Bollikolla, H. B. . (2017). Synthesis and Characterization of Novel Atazanavir Analogs. Caribbean Journal of Sciences and Technology, 5(1), 94–105. Retrieved from http://caribjscitech.com/index.php/cjst/article/view/7

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Section

Research Article