Studies toward the total synthesis of (+)-Discodermolide: Desymmetrization approach

10.55434/CBI.2022.10105

Authors

  • Narsimhaswamy Dubasi Analyst
  • RVarala

DOI:

https://doi.org/10.55434/CBI.2022.10105

Keywords:

( )-Discodermolide, Retrosynthesis, Fragment or sub-unit, Anti-cancer activity, Natural products

Abstract

A new synthetic strategy for the construction of C-1 to C-7 and C-8 to C-15 subunits of (+)-discodermolide, a highly potent anticancer natural product, is reported in which we have exploited desymmetrization approach to create six stereogenic centers at once and stigmatic elements of the successful methodology include elaboration of two advanced fragments from a common precursor.

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A new synthetic strategy for the construction of C-1 to C-7 and C-8 to C-15 subunits of (+)-discodermolide, a highly potent anticancer natural product, is reported in which we have exploited desymmetrization approach to create six stereogenic centers at once and stigmatic elements of the successful methodology include elaboration of two advanced fragments from a common precursor.

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Published

30-06-2022

How to Cite

Dubasi, N., & Varala, R. (2022). Studies toward the total synthesis of (+)-Discodermolide: Desymmetrization approach: 10.55434/CBI.2022.10105. Caribbean Journal of Sciences and Technology, 10(1), 28–35. https://doi.org/10.55434/CBI.2022.10105

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Section

Research Article