Ammonium acetate as a Dual Reagent-Catalyst Role in Efficient Synthesis of 2,4,6-Trisubstituted 1,3,5-triazines from Aldehydes

10.55434/CBI.2022.20106

Abstract

The synthesis of 2,4,6-triaryl-1,3,5-triazines using iron-catalyzed cyclization of aldehydes with NH₄I as the only nitrogen source is shown to be an easy, atom-efficient process. This method provides symmetrical 2,4,6-trisubstituted and unsymmetrical 1,3,5-triazines with yields ranging from 52% to 85% and operates without difficulty in an environment of air. The current methodology offers a simple and atom-efficient way for making 2,4,6-trisubstituted 1,3,5-triazines that uses an affordable, widely accessible ammonium salt as the only nitrogen source.