Caribbean Journal of Sciences and Technology https://caribjscitech.com/index.php/cjst <p style="text-align: justify;"><em>Caribbean Journal of Science and Technology (CJST)</em> is a half yearly (from 2022), international, open access, peer-reviewed Journal and committed to publish multidisciplinary subjects related to biological, chemical, pharmaceutical, and all technological sciences. Further, CJST preferably encourages articles with novelty. CJST publishes manuscripts of the type Full-length research articles, Review articles, Mini-reviews, Short communications, Case Studies, Perspectives and Letters to the Editor.</p> ChemBio International en-US Caribbean Journal of Sciences and Technology 0799-3757 DERMATOPHYTES AND DERMATOPHYTOSES ACQUISITION AMONG SCHOOL-AGE CHILDREN IN CAMEROUN, IVORY COAST, MALI AND NIGERIA: A SYSTEMATIC REVIEW https://caribjscitech.com/index.php/cjst/article/view/273 <p>Fungal infections tend to be the most commonly diagnosed skin disease in Africa and with a high percentage of incidence among school-age children. This epidemiological survey summarized the epidemiological trends of dermatophytoses reported in West African countries. The review protocol was done in March 2019 through a literature search using Medline, Google Scholar, PubMed and African Journals Online (AJOL) databases to download all published papers reporting fungal infections among school-age children in West Africa. The period included in the reports was February 2007 to January 2019. A total number of 36,299 samples were investigated by the authors across West African countries and a total of 6262 were recorded positive with dermatophytes segregated by male and female. Tinea capitis has a prevalence of 44.4% and mainly affected children of ages 6–10 years (78.09%). This was followed by Tinea corporis and Tinea unguium with a prevalence of 19.4% and 13.9% respectively. <em>Trichophyton </em>species [n=67 (54.92%)]<em>, Microsporum </em>species [n=34 (27.87%)], <em>Aspergillus </em>species [n=6 (4.92%)] and<em> Epidermophyton </em>species [n=5 (4.10%)] are most keratinophilic fungi isolated. The scalp [n=2471 (38.51%)]<em>, </em>scalp and body [n= 2142 (33.38%)] and toe and nails [n=479 (7.46%)] were the most affected body parts recorded. Tinea capitis remains a common infection among the subjects, and various interventions are needed to reduce the spread of dermatophytic infections in this category.</p> Oluwole David Ogunleye O Adeola PO Olawusi Ac Owabumoye JB Ogidi C Adetulubo AD Copyright (c) 2022 Caribbean Journal of Sciences and Technology 2022-11-24 2022-11-24 10 2 17 23 10.55434/CBI.2022.20103 QUANTIFICATION OF IMPURITY-E IN VORICONAZOLE POWDER FOR SOLUTION FOR INFUSION (200 MG/VIAL) BY USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY https://caribjscitech.com/index.php/cjst/article/view/250 <p>A novel stability indicating liquid chromatographic method was developed and validated for the quantification of impurity<strong>-E</strong>(<strong>(±)-β-Camphorsulfonic acid, (±)-Camphor-10-sulfonic acid)</strong>in Voriconazole powder for solution for infusion formulation. The separation was achieved on Novapak (150 x 3.9 mm, 4 μm) column using a movable segment consisting of pH 5.0 acetate buffer and acetonitrile gradient elution mode, at a flow rate of 1.0 ml/min. Column oven maintained at 35°C, inoculation quantity 50 µl, sample cooler temperature 5 °C and detection wavelength 286 nm. Chromatographic resolution between impurity-E and Voriconazole was found to be 22.1. Technique was extensively validated for the quantification of impurity-E in Voriconazole powder for solution for infusion formulation and established to be vigorous. Method was established extremely specific as all other related impurities were separated from the impurity-E. The Limit of quantitation (LOQ) and limit of detection (LOD) for impurity-E were 6.0μg/ml and 2.0 μg/ml respectively.</p> Sanni Babu Najana Bala Murali Krishna Khandapu Copyright (c) 2022 Caribbean Journal of Sciences and Technology 2022-09-18 2022-09-18 10 2 1 9 10.55434/CBI.2022.20101 Zn(OAc)2.2H2O-Catalyzed C3-alkylation and O-alkylation of 4-Hydroxycoumarin derivatives https://caribjscitech.com/index.php/cjst/article/view/271 <p>For the C3-alkylation and O-alkylation of 4-hydroxycoumarins with benzylic, allylic, and corresponding acetates, respectively, under neat conditions at 60 <sup>0</sup>C with high product yield, Zn(OAc)<sub>2</sub>.2H2O has been found to be an effective reusable solid superacid catalyst.</p> Sravan Kumar Bandaru Matthew C. Risi Copyright (c) 2022 Caribbean Journal of Sciences and Technology 2022-09-30 2022-09-30 10 2 10 16 10.55434/CBI.2022.20102