Fenoterol Alters Lipid Composition and Fatty Acids Profile Of Small Intestine In Swiss Albino Male Mice

Abstract

The goal of this study was to evaluate the influence of fenoterol a beta agonist on lipid composition and fatty acid profile in the small intestinal mucosa of swiss albino male mice. Fenoterol was orally administered with 1.5mg/kg body wt. for 28 days. Fenoterol treated mice had significantly lower conc. of cholesterol, phospholipid and triglycerides in the duodenum, jejunum and ileum compared with normal. Fatty acid composition of the intestinal mucosa was severely affected by fenoterol treatment. Increase in the relative percentage of long chain poly unsaturated fatty acids in drug treated mice paralleled to lower fatty acids proportions in normal mice duodenum, jejunum and ileum. The structure of small intestine was severely affected as assessed by histopathological studies. Our results suggest that oral administration of fenoterol at 28 days stage dramatically modifies intestinal membrane lipid composition. Changes in the lipid composition of the small intestinal mucosa and in phospholipid distribution as well as in the fatty acid profile may alter membrane fluidity and organization. These alterations appear to affect the activity of membrane-bound hydrolytic enzymes.