THREE DRUG COMBINATION OF OLMESARTAN, CILNIDIPINE AND CHLORTHALIDONE QUANTITATIVE DETERMINATION BY USING UPLC

Authors

  • R.Veereswara Rao
  • Dr.Abhijit M Deshmukh
  • Dr.J Madhu Rajendra Kumar

Abstract

Olmesartan, Cilnidipine and Chlorthalidone medicinal products are used to treat calcium channel blocking, high blood pressure and diuretic treatment. UPLC method was developed and validated. Chromatographic conditions are 1mL of OPA in a 1000ml of water and Acetonitrile 45:55 v/v as mobile phase, flow rate 0.3 ml/min, column SB C8 100x 3.0, 1.8mm, wave length 260nm, column temperature 30°C, injection volume 5µL, run time 4 min, diluent water and acetonitrile (50:50 v/v). Validated UPLC method can be used to quantify these three drugs in three combination product.

Metrics

Metrics Loading ...

Downloads

Published

31-12-2018

How to Cite

Rao, R., M Deshmukh, D., & Rajendra Kumar, D. M. (2018). THREE DRUG COMBINATION OF OLMESARTAN, CILNIDIPINE AND CHLORTHALIDONE QUANTITATIVE DETERMINATION BY USING UPLC. Caribbean Journal of Sciences and Technology, 6(1), 55–59. Retrieved from https://caribjscitech.com/index.php/cjst/article/view/18

Issue

Section

Research Article