Evaluation of the antioxidant activity and nephroprotective Effects of Guiera Senegalensis Ethanolic Extract on Gentamicin-induced Nephrotoxicity in rats

Abstract

The present study was undertaken to evaluate Guiera Senegalensis protective effects on gentamicin-induced nephrotoxicity in rats. 40 albino rats of either sex, weighing 150-200g were divided into 4 groups; Control group, gentamicin 80 mg/kg, i.p., for 6 days, Guiera Senegalensis 250 and 500 mg/kg i.p., for 10 days, Guiera Senegalensis 4 days prior and concurrently with gentamicin for 6 days. Radical scavenging activity of Guiera Senegalensis was determined; Catalase and super oxide dismutase, urea and creatinine in serum and urine were analyzed. Gentamicin administration caused nephrotoxicity as evidenced by the remarkable elevation of urea and creatinine in serum and urine. Urea and creatinine in serum and urine were increased in response of gentamicin administration compared to the control group. (55.95 ± 2.40 mg/dl, 3.82 ± 0.33 mg/dl, 1219.2 ± 36.49 mg/dl and 139.4 ± 20.27 mg/dl respectively).Co-administration of Guiera Senegalensis with gentamicin decreased the rises of these parameters. To conclude, our data suggest that supplementation of Guiera Senegalensis may be useful in reducing gentamicin nephrotoxicity in rats.