Studies toward the total synthesis of (+)-Discodermolide: Desymmetrization approach

DOI: https://doi.org/10.55434/CBI.2022.10105

Authors

  • Narasimhaswamy D Saimerak Pharma
  • Ravi Varala scrips pharma ltd

Keywords:

( )-Discodermolide, Retrosynthesis, Fragment or sub-unit, Anti-cancer activity, Natural products

Abstract

A new synthetic strategy for the construction of C-1 to C-7 and C-8 to C-15 subunits of (+)-discodermolide, a highly potent anticancer natural product, is reported in which we have exploited desymmetrization approach to create six stereogenic centers at once and stigmatic elements of the successful methodology include elaboration of two advanced fragments from a common precursor.

 

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Published

30-06-2022

How to Cite

D, N., & Varala, R. . (2022). Studies toward the total synthesis of (+)-Discodermolide: Desymmetrization approach: DOI: https://doi.org/10.55434/CBI.2022.10105. Caribbean Journal of Sciences and Technology, 10(1), 28–35. Retrieved from https://caribjscitech.com/index.php/cjst/article/view/252

Issue

Section

Research Article

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