Studies toward the total synthesis of (+)-Discodermolide: Desymmetrization approach

DOI: https://doi.org/10.55434/CBI.2022.10105

Abstract

A new synthetic strategy for the construction of C-1 to C-7 and C-8 to C-15 subunits of (+)-discodermolide, a highly potent anticancer natural product, is reported in which we have exploited desymmetrization approach to create six stereogenic centers at once and stigmatic elements of the successful methodology include elaboration of two advanced fragments from a common precursor.